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Patients with epidermal growth factor receptor ( EGFR ) expressing advanced squamous non-small-cell lung cancer benefit most from Necitumumab ( Portrazza ) added to Gemcitabine and Cisplatin chemother ...


The aim of a study was to explore the efficacy and safety of Crizotinib ( Xalkori ) versus Platinum-based double agent chemotherapy as the first-line treatment in patients with advanced anaplastic lym ...


A study sought to test the hypothesis that in persons with episodic migraine, asthma is a risk factor for the onset of chronic migraine. Migraine and asthma are comorbid chronic disorders with epis ...


Studies have suggested a procoagulant state may be involved in promoting fibrosis via cell-surface receptor–mediated pathways providing biological plausibility for a mechanistic link between thrombosi ...


Idiopathic pulmonary fibrosis ( IPF ) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause occurring in adults. Radiologic and/or histopathologic patterns are ...


In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal anti ...


Eradication and suppression of Pseudomonas aeruginosa ( P. aeruginosa ) is a key priority in national guidelines for bronchiectasis, and is a major focus of drug development and clinical trials. An ac ...


Chronic obstructive pulmonary disease ( COPD ) is characterized by neutrophil-dominated airway mucosal inflammation and elevated neutrophil counts in sputum and lung tissue. CXC chemokine receptor 2 ( ...


No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa ( P. aeruginosa ) colonisation in bronchiectasis not due to cystic fibrosis. Researchers have evaluated the e ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive diffuse lung disease associated with an increased risk of lung cancer. Patients with idiopathic pulmonary fibrosis sometimes develop a life-threa ...


A study has examined the correlation between pre-operative coronary artery disease ( CAD ) and post-operative cardiovascular events in lung transplant recipients. Consecutive isolated lung transpla ...


This randomised double-blind placebo-controlled parallel-group multicentre phase IIa study evaluated the effect of the CXCR2 antagonist AZD5069 on sputum neutrophil counts in adults with bronchiectasi ...


Several cases of Burkholderia pseudomallei ( B. pseudomallei ) infection in cystic fibrosis have been previously reported. The aim of a study was to identify all cases globally, risk factors for acqui ...


Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postope ...


Multidrug-resistant ( MDR ) bacteria are a growing concern worldwide. The aim of this study was to describe the epidemiology and risk factors of MDR bacteria detected in respiratory invasive samples d ...


Bedaquiline ( Sirturo ) is a new antibiotic that was approved for the treatment of multidrug-resistant ( MDR ) tuberculosis. The short-term microbiological efficacy and the tolerability profile of Bed ...


Haemoptysis is a serious symptom with various aetiologies. The aim of a study was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income countr ...


Of the 1.5 million people diagnosed with pleural effusion in the USA annually, approximately 178 000 undergo thoracentesis. While it is known that malignant pleural effusion portends a poor prognosis, ...


Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option. A study aimed to assess the impact of sequential combination ...


Decreased physical performance due to loss of muscle mass ( i.e. sarcopenia ) is prevalent in ageing and appears more pronounced in chronic disease. A comprehensive profile of the sarcopenic phenotype ...


The safety and efficacy of adding Bosentan ( Tracleer ) to Sildenafil ( Revatio ) in pulmonary arterial hypertension ( PAH ) patients was investigated. In this prospective, double-blind, event-driv ...


MicroRNAs ( miRNAs ) are endogenous small ( 19-24 nt long ) noncoding RNAs that regulate gene expression in a sequence specific manner. An increasing association between miRNA and cancer has been re ...


mTOR inhibitors have clinically significant activity against various malignancies, such as renal cell carcinoma and breast cancer, but their use can be complicated by several toxicities. Interstitia ...


Epidermal growth factor receptor-tyrosine kinase inhibitors ( EGFR-TKIs ) are a critical member of systemic therapy for advanced non-small-cell lung cancer ( NSCLC ). Erlotinib ( Tarceva ) is the ...


In the two replicate, placebo-controlled, 52-week, phase III INPULSIS trials, Nintedanib ( Ofev ) 150 mg twice daily significantly reduced the annual rate of decline in forced vital capacity ( FVC ), ...


The role of Tiotropium ( Spiriva ) for the treatment of adolescents with asthma has not yet been clearly defined. A study has assessed the efficacy and safety of inhaled Tiotropium in adolescents with ...


Data were reported from across AstraZeneca’s industry-leading lung cancer portfolio at the World Conference on Lung Cancer ( WCLC ) 2015, in Denver, Colorado ( U.S. ). 25 abstracts ( including 9 oral ...


Community-acquired pneumonia ( CAP ) causes considerable morbidity and mortality in adults, particularly in the elderly. Structured searches of PubMed were conducted to identify up-to-date informat ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive disease characterised by dyspnea and loss of lung function. Using pooled data from the replicate, randomized, 52-week, placebo-controlled INPU ...


Alectinib ( Alecensa ) is a second-generation, orally active, potent and highly selective inhibitor of anaplastic lymphoma kinase ( ALK ). Alectinib is approved for the treatment of ALK fusion-gen ...


Lung cancer patients with comorbid conditions such as chronic obstructive pulmonary disease ( COPD ), diabetes mellitus, or congestive heart failure had a higher risk of death than lung cancer patient ...


The maturation, recruitment and survival of eosinophils in the respiratory tract are determined by IL-3, GM-CSF, but especially by IL-5, which has a key role in mediating airways eosinophilic inflamma ...


Additional results from an interim analysis of a pivotal phase 2b study of Dupilumab in adult patients with moderate-to-severe asthma who are uncontrolled despite treatment with inhaled corticosteroid ...


A study has investigated the effects on 24-h lung function and lung volume of a once-daily fixed-dose combination ( FDC ) of the long-acting muscarinic antagonist Tiotropium and the long-acting beta2- ...


Long-acting inhaled bronchodilators, including anticholinergic Tiotropium ( Spiriva ), are recommended for the maintenance therapy of chronic obstructive pulmonary disease ( COPD ). It has been show ...


Long-term exposure to ambient air pollution is associated with cerebrovascular disease and cognitive impairment, but whether it is related to structural changes in the brain is not clear. Researcher ...


EGFR belongs to the ErbB family of transmembrane tyrosine kinase receptors ( ErbB comprises ErbB1/EGFR/HER1, ErbB2/HER2/NEU, ErbB3/HER3, and ErbB4/HER4 ). EGFR exists as a monomer and can initiate ...


Chronic obstructive pulmonary disease ( COPD ) is frequently accompanied by multimorbidities in affected patients. Even though the majority of these comorbidities are also related to advanced age and ...


Tiotropium plus Olodaterol ( Europe: Spiolto Respimat; US: Stiolto Respimat ) improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease ( COPD ). The O ...


In a study with mice, researchers at Johns Hopkins Bloomberg School of Public Health have found that e-cigarettes compromise the immune system in the lungs and generate some of the same potentially da ...


Key goals in the treatment of community-acquired pneumonia ( CAP ) include early response to treatment and achievement of clinical stability. The US FDA ( Food and Drug Admnistration ) recommends ea ...


Although high-dose N-Acetylcysteine ( NAC; Acetylcysteine; Fluimucil ) has been suggested to reduce COPD ( chronic obstructive pulmonary disease ) exacerbations, it is unclear which category of patien ...


Ambrisentan ( US: Letairis; EU: Volibris ) is an oral selective endothelin receptor antagonist licensed for use in pulmonary arterial hypertension ( PAH ). There are few data on clinical use and lon ...


Riociguat ( Adempas ) is a soluble guanylate cyclase stimulator approved for the treatment of inoperable and persistent / recurrent chronic thromboembolic pulmonary hypertension ( CTEPH ). In the ...


Researchers have conducted a meta-analysis of randomised trials to evaluate the efficacy and safety of inhaled antibiotics in patients with stable non-cystic fibrosis ( CF ) bronchiectasis. 12 tria ...


Many patients with severe asthma require regular treatment with oral glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of systemic glucocorticoids can result in se ...


Pulmonary vascular leakage occurs early in acute respiratory distress syndrome ( ARDS ). Mortality is high ( 35–45% ), but no effective pharmacotherapy exists. Production of anti-inflammatory adenosin ...


Pirfenidone ( Esbriet ) is a novel antifibrotic drug for the treatment of mild-to-moderate idiopathic pulmonary fibrosis ( IPF ). However, adverse events may offset treatment benefits and compliance. ...


Aclidinium bromide / Formoterol fumarate ( 400/12 mcg ) is a fixed dose combination of two approved long-acting bronchodilators with different mechanisms of action and similar pharmocodynamic profiles ...


Increased arterial stiffness as measured by aortic pulse wave velocity ( aPWV ) predicts cardiovascular events and mortality and is elevated in patients with COPD ( chronic obstructive pulmonary disea ...