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Multidrug-resistant ( MDR ) bacteria are a growing concern worldwide. The aim of this study was to describe the epidemiology and risk factors of MDR bacteria detected in respiratory invasive samples d ...


Bedaquiline ( Sirturo ) is a new antibiotic that was approved for the treatment of multidrug-resistant ( MDR ) tuberculosis. The short-term microbiological efficacy and the tolerability profile of Bed ...


Haemoptysis is a serious symptom with various aetiologies. The aim of a study was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income countr ...


Of the 1.5 million people diagnosed with pleural effusion in the USA annually, approximately 178 000 undergo thoracentesis. While it is known that malignant pleural effusion portends a poor prognosis, ...


Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option. A study aimed to assess the impact of sequential combination ...


Decreased physical performance due to loss of muscle mass ( i.e. sarcopenia ) is prevalent in ageing and appears more pronounced in chronic disease. A comprehensive profile of the sarcopenic phenotype ...


The safety and efficacy of adding Bosentan ( Tracleer ) to Sildenafil ( Revatio ) in pulmonary arterial hypertension ( PAH ) patients was investigated. In this prospective, double-blind, event-driv ...


MicroRNAs ( miRNAs ) are endogenous small ( 19-24 nt long ) noncoding RNAs that regulate gene expression in a sequence specific manner. An increasing association between miRNA and cancer has been re ...


mTOR inhibitors have clinically significant activity against various malignancies, such as renal cell carcinoma and breast cancer, but their use can be complicated by several toxicities. Interstitia ...


Epidermal growth factor receptor-tyrosine kinase inhibitors ( EGFR-TKIs ) are a critical member of systemic therapy for advanced non-small-cell lung cancer ( NSCLC ). Erlotinib ( Tarceva ) is the ...


In the two replicate, placebo-controlled, 52-week, phase III INPULSIS trials, Nintedanib ( Ofev ) 150 mg twice daily significantly reduced the annual rate of decline in forced vital capacity ( FVC ), ...


The role of Tiotropium ( Spiriva ) for the treatment of adolescents with asthma has not yet been clearly defined. A study has assessed the efficacy and safety of inhaled Tiotropium in adolescents with ...


Data were reported from across AstraZeneca’s industry-leading lung cancer portfolio at the World Conference on Lung Cancer ( WCLC ) 2015, in Denver, Colorado ( U.S. ). 25 abstracts ( including 9 oral ...


Community-acquired pneumonia ( CAP ) causes considerable morbidity and mortality in adults, particularly in the elderly. Structured searches of PubMed were conducted to identify up-to-date informat ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive disease characterised by dyspnea and loss of lung function. Using pooled data from the replicate, randomized, 52-week, placebo-controlled INPU ...