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Lung cancer patients with comorbid conditions such as chronic obstructive pulmonary disease ( COPD ), diabetes mellitus, or congestive heart failure had a higher risk of death than lung cancer patient ...


The maturation, recruitment and survival of eosinophils in the respiratory tract are determined by IL-3, GM-CSF, but especially by IL-5, which has a key role in mediating airways eosinophilic inflamma ...


Additional results from an interim analysis of a pivotal phase 2b study of Dupilumab in adult patients with moderate-to-severe asthma who are uncontrolled despite treatment with inhaled corticosteroid ...


A study has investigated the effects on 24-h lung function and lung volume of a once-daily fixed-dose combination ( FDC ) of the long-acting muscarinic antagonist Tiotropium and the long-acting beta2- ...


Long-acting inhaled bronchodilators, including anticholinergic Tiotropium ( Spiriva ), are recommended for the maintenance therapy of chronic obstructive pulmonary disease ( COPD ). It has been show ...


Long-term exposure to ambient air pollution is associated with cerebrovascular disease and cognitive impairment, but whether it is related to structural changes in the brain is not clear. Researcher ...


EGFR belongs to the ErbB family of transmembrane tyrosine kinase receptors ( ErbB comprises ErbB1/EGFR/HER1, ErbB2/HER2/NEU, ErbB3/HER3, and ErbB4/HER4 ). EGFR exists as a monomer and can initiate ...


Chronic obstructive pulmonary disease ( COPD ) is frequently accompanied by multimorbidities in affected patients. Even though the majority of these comorbidities are also related to advanced age and ...


Tiotropium plus Olodaterol ( Europe: Spiolto Respimat; US: Stiolto Respimat ) improves lung function and symptoms compared to monotherapies in chronic obstructive pulmonary disease ( COPD ). The O ...


In a study with mice, researchers at Johns Hopkins Bloomberg School of Public Health have found that e-cigarettes compromise the immune system in the lungs and generate some of the same potentially da ...


Key goals in the treatment of community-acquired pneumonia ( CAP ) include early response to treatment and achievement of clinical stability. The US FDA ( Food and Drug Admnistration ) recommends ea ...


Although high-dose N-Acetylcysteine ( NAC; Acetylcysteine; Fluimucil ) has been suggested to reduce COPD ( chronic obstructive pulmonary disease ) exacerbations, it is unclear which category of patien ...


Ambrisentan ( US: Letairis; EU: Volibris ) is an oral selective endothelin receptor antagonist licensed for use in pulmonary arterial hypertension ( PAH ). There are few data on clinical use and lon ...


Riociguat ( Adempas ) is a soluble guanylate cyclase stimulator approved for the treatment of inoperable and persistent / recurrent chronic thromboembolic pulmonary hypertension ( CTEPH ). In the ...


Researchers have conducted a meta-analysis of randomised trials to evaluate the efficacy and safety of inhaled antibiotics in patients with stable non-cystic fibrosis ( CF ) bronchiectasis. 12 tria ...