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The phase 2 ATLANTIC study has investigated the anti-PD-L1 antibody Durvalumab ( Imfinzi ) in heavily pretreated patients with advanced non-small cell lung cancer ( NSCLC ). Researchers have repor ...


CheckMate 227, a phase 3 study of first-line Nivolumab ( Opdivo ) plus Ipilimumab ( Yervoy ), Nivolumab, or Nivolumab plus chemotherapy vs chemotherapy in advanced non-small cell lung cancer ( NSCLC ) ...


ALTA trial has evaluated 2 doses of the ALK inhibitor Brigatinib post-Crizotinib. Overall objective response rate ( ORR ) contains both CNS and extra-CNS target lesion data. In ALTA, stratification ...


CheckMate 227 is a large phase 3 study of first-line Nivolumab plus Ipilimumab, Nivolumab, or Nivolumab plus chemotherapy vs chemotherapy in advanced non-small cell lung cancer ( NSCLC ). The stud ...


Despite advancement of 2nd generation ALK tyrosine kinase inhibitors ( TKIs ), patients with ALK+ non-small cell lung cancer ( NSCLC ) continue to develop resistance and CNS metastases become more d ...


Small-cell lung cancer ( SCLC ) is an aggressive lung cancer with high rate of relapse following initial treatment; immunotherapy holds potential as a novel treatment option for this disease. The an ...


Alectinib ( Alecensa ) has proven systemic and CNS efficacy in patients with ALK+ aNSCLC ( advanced non-small cell lung cancer ) ( ALEX trial ). T umor cell death caused by Alectinib may release anti ...


Approximately 10% of EGFR mutants harbor uncommon mutations, which represent a heterogeneous group of rare molecular alterations within exons 18-21 and the sensitivity to EGFR tyrosine kinase inhibito ...


Dronabinol ( Marinol ) has shown promise for obstructive sleep apnea ( OSA ) pharmacotherapy in a small dose-escalation pilot study. Phase II PACE ( Pharmacotherapy of Apnea by Cannabimimetic Enhan ...


Previous studies have suggested that acute respiratory infection ( ARI ) and nonsteroidal anti-inflammatory drugs ( NSAIDs ) use could trigger acute myocardial infarction ( AMI ). In some countries, ...


The European Respiratory Journal ( ERJ ) published a manuscript entitled, FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF, from a phase ...


Patients with epidermal growth factor receptor ( EGFR ) expressing advanced squamous non-small-cell lung cancer benefit most from Necitumumab ( Portrazza ) added to Gemcitabine and Cisplatin chemother ...


The aim of a study was to explore the efficacy and safety of Crizotinib ( Xalkori ) versus Platinum-based double agent chemotherapy as the first-line treatment in patients with advanced anaplastic lym ...


A study sought to test the hypothesis that in persons with episodic migraine, asthma is a risk factor for the onset of chronic migraine. Migraine and asthma are comorbid chronic disorders with epis ...


Studies have suggested a procoagulant state may be involved in promoting fibrosis via cell-surface receptor–mediated pathways providing biological plausibility for a mechanistic link between thrombosi ...