Pulmonology Xagena
Despite advancement of 2nd generation ALK tyrosine kinase inhibitors ( TKIs ), patients with ALK+ non-small cell lung cancer ( NSCLC ) continue to develop resistance and CNS metastases become more d ...
Small-cell lung cancer ( SCLC ) is an aggressive lung cancer with high rate of relapse following initial treatment; immunotherapy holds potential as a novel treatment option for this disease. The an ...
Alectinib ( Alecensa ) has proven systemic and CNS efficacy in patients with ALK+ aNSCLC ( advanced non-small cell lung cancer ) ( ALEX trial ). T umor cell death caused by Alectinib may release anti ...
Approximately 10% of EGFR mutants harbor uncommon mutations, which represent a heterogeneous group of rare molecular alterations within exons 18-21 and the sensitivity to EGFR tyrosine kinase inhibito ...
Dronabinol ( Marinol ) has shown promise for obstructive sleep apnea ( OSA ) pharmacotherapy in a small dose-escalation pilot study. Phase II PACE ( Pharmacotherapy of Apnea by Cannabimimetic Enhan ...
Previous studies have suggested that acute respiratory infection ( ARI ) and nonsteroidal anti-inflammatory drugs ( NSAIDs ) use could trigger acute myocardial infarction ( AMI ). In some countries, ...
The European Respiratory Journal ( ERJ ) published a manuscript entitled, FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF, from a phase ...
Patients with epidermal growth factor receptor ( EGFR ) expressing advanced squamous non-small-cell lung cancer benefit most from Necitumumab ( Portrazza ) added to Gemcitabine and Cisplatin chemother ...
The aim of a study was to explore the efficacy and safety of Crizotinib ( Xalkori ) versus Platinum-based double agent chemotherapy as the first-line treatment in patients with advanced anaplastic lym ...
A study sought to test the hypothesis that in persons with episodic migraine, asthma is a risk factor for the onset of chronic migraine. Migraine and asthma are comorbid chronic disorders with epis ...
Studies have suggested a procoagulant state may be involved in promoting fibrosis via cell-surface receptor–mediated pathways providing biological plausibility for a mechanistic link between thrombosi ...
Idiopathic pulmonary fibrosis ( IPF ) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause occurring in adults. Radiologic and/or histopathologic patterns are ...
In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal anti ...
Eradication and suppression of Pseudomonas aeruginosa ( P. aeruginosa ) is a key priority in national guidelines for bronchiectasis, and is a major focus of drug development and clinical trials. An ac ...
Chronic obstructive pulmonary disease ( COPD ) is characterized by neutrophil-dominated airway mucosal inflammation and elevated neutrophil counts in sputum and lung tissue. CXC chemokine receptor 2 ( ...
