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Idiopathic pulmonary fibrosis ( IPF ) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause occurring in adults. Radiologic and/or histopathologic patterns are ...


In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal anti ...


Eradication and suppression of Pseudomonas aeruginosa ( P. aeruginosa ) is a key priority in national guidelines for bronchiectasis, and is a major focus of drug development and clinical trials. An ac ...


Chronic obstructive pulmonary disease ( COPD ) is characterized by neutrophil-dominated airway mucosal inflammation and elevated neutrophil counts in sputum and lung tissue. CXC chemokine receptor 2 ( ...


No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa ( P. aeruginosa ) colonisation in bronchiectasis not due to cystic fibrosis. Researchers have evaluated the e ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive diffuse lung disease associated with an increased risk of lung cancer. Patients with idiopathic pulmonary fibrosis sometimes develop a life-threa ...


A study has examined the correlation between pre-operative coronary artery disease ( CAD ) and post-operative cardiovascular events in lung transplant recipients. Consecutive isolated lung transpla ...


This randomised double-blind placebo-controlled parallel-group multicentre phase IIa study evaluated the effect of the CXCR2 antagonist AZD5069 on sputum neutrophil counts in adults with bronchiectasi ...


Several cases of Burkholderia pseudomallei ( B. pseudomallei ) infection in cystic fibrosis have been previously reported. The aim of a study was to identify all cases globally, risk factors for acqui ...


Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postope ...


Multidrug-resistant ( MDR ) bacteria are a growing concern worldwide. The aim of this study was to describe the epidemiology and risk factors of MDR bacteria detected in respiratory invasive samples d ...


Bedaquiline ( Sirturo ) is a new antibiotic that was approved for the treatment of multidrug-resistant ( MDR ) tuberculosis. The short-term microbiological efficacy and the tolerability profile of Bed ...


Haemoptysis is a serious symptom with various aetiologies. The aim of a study was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income countr ...


Of the 1.5 million people diagnosed with pleural effusion in the USA annually, approximately 178 000 undergo thoracentesis. While it is known that malignant pleural effusion portends a poor prognosis, ...


Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option. A study aimed to assess the impact of sequential combination ...