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No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa ( P. aeruginosa ) colonisation in bronchiectasis not due to cystic fibrosis. Researchers have evaluated the e ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive diffuse lung disease associated with an increased risk of lung cancer. Patients with idiopathic pulmonary fibrosis sometimes develop a life-threa ...


A study has examined the correlation between pre-operative coronary artery disease ( CAD ) and post-operative cardiovascular events in lung transplant recipients. Consecutive isolated lung transpla ...


This randomised double-blind placebo-controlled parallel-group multicentre phase IIa study evaluated the effect of the CXCR2 antagonist AZD5069 on sputum neutrophil counts in adults with bronchiectasi ...


Several cases of Burkholderia pseudomallei ( B. pseudomallei ) infection in cystic fibrosis have been previously reported. The aim of a study was to identify all cases globally, risk factors for acqui ...


Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postope ...


Multidrug-resistant ( MDR ) bacteria are a growing concern worldwide. The aim of this study was to describe the epidemiology and risk factors of MDR bacteria detected in respiratory invasive samples d ...


Bedaquiline ( Sirturo ) is a new antibiotic that was approved for the treatment of multidrug-resistant ( MDR ) tuberculosis. The short-term microbiological efficacy and the tolerability profile of Bed ...


Haemoptysis is a serious symptom with various aetiologies. The aim of a study was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income countr ...


Of the 1.5 million people diagnosed with pleural effusion in the USA annually, approximately 178 000 undergo thoracentesis. While it is known that malignant pleural effusion portends a poor prognosis, ...


Pulmonary arterial hypertension is a severe disease with a complex pathogenesis, for which combination therapy is an attractive option. A study aimed to assess the impact of sequential combination ...


Decreased physical performance due to loss of muscle mass ( i.e. sarcopenia ) is prevalent in ageing and appears more pronounced in chronic disease. A comprehensive profile of the sarcopenic phenotype ...


The safety and efficacy of adding Bosentan ( Tracleer ) to Sildenafil ( Revatio ) in pulmonary arterial hypertension ( PAH ) patients was investigated. In this prospective, double-blind, event-driv ...


MicroRNAs ( miRNAs ) are endogenous small ( 19-24 nt long ) noncoding RNAs that regulate gene expression in a sequence specific manner. An increasing association between miRNA and cancer has been re ...


mTOR inhibitors have clinically significant activity against various malignancies, such as renal cell carcinoma and breast cancer, but their use can be complicated by several toxicities. Interstitia ...