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Epidermal growth factor receptor-tyrosine kinase inhibitors ( EGFR-TKIs ) are a critical member of systemic therapy for advanced non-small-cell lung cancer ( NSCLC ). Erlotinib ( Tarceva ) is the ...


In the two replicate, placebo-controlled, 52-week, phase III INPULSIS trials, Nintedanib ( Ofev ) 150 mg twice daily significantly reduced the annual rate of decline in forced vital capacity ( FVC ), ...


The role of Tiotropium ( Spiriva ) for the treatment of adolescents with asthma has not yet been clearly defined. A study has assessed the efficacy and safety of inhaled Tiotropium in adolescents with ...


Data were reported from across AstraZeneca’s industry-leading lung cancer portfolio at the World Conference on Lung Cancer ( WCLC ) 2015, in Denver, Colorado ( U.S. ). 25 abstracts ( including 9 oral ...


Community-acquired pneumonia ( CAP ) causes considerable morbidity and mortality in adults, particularly in the elderly. Structured searches of PubMed were conducted to identify up-to-date informat ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive disease characterised by dyspnea and loss of lung function. Using pooled data from the replicate, randomized, 52-week, placebo-controlled INPU ...


Alectinib ( Alecensa ) is a second-generation, orally active, potent and highly selective inhibitor of anaplastic lymphoma kinase ( ALK ). Alectinib is approved for the treatment of ALK fusion-gen ...


Lung cancer patients with comorbid conditions such as chronic obstructive pulmonary disease ( COPD ), diabetes mellitus, or congestive heart failure had a higher risk of death than lung cancer patient ...


The maturation, recruitment and survival of eosinophils in the respiratory tract are determined by IL-3, GM-CSF, but especially by IL-5, which has a key role in mediating airways eosinophilic inflamma ...


Additional results from an interim analysis of a pivotal phase 2b study of Dupilumab in adult patients with moderate-to-severe asthma who are uncontrolled despite treatment with inhaled corticosteroid ...


A study has investigated the effects on 24-h lung function and lung volume of a once-daily fixed-dose combination ( FDC ) of the long-acting muscarinic antagonist Tiotropium and the long-acting beta2- ...


Long-acting inhaled bronchodilators, including anticholinergic Tiotropium ( Spiriva ), are recommended for the maintenance therapy of chronic obstructive pulmonary disease ( COPD ). It has been show ...


Long-term exposure to ambient air pollution is associated with cerebrovascular disease and cognitive impairment, but whether it is related to structural changes in the brain is not clear. Researcher ...


EGFR belongs to the ErbB family of transmembrane tyrosine kinase receptors ( ErbB comprises ErbB1/EGFR/HER1, ErbB2/HER2/NEU, ErbB3/HER3, and ErbB4/HER4 ). EGFR exists as a monomer and can initiate ...


Chronic obstructive pulmonary disease ( COPD ) is frequently accompanied by multimorbidities in affected patients. Even though the majority of these comorbidities are also related to advanced age and ...