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The European Respiratory Journal ( ERJ ) published a manuscript entitled, FG-3019 anti-connective tissue growth factor monoclonal antibody: results of an open-label clinical trial in IPF, from a phase ...


Patients with epidermal growth factor receptor ( EGFR ) expressing advanced squamous non-small-cell lung cancer benefit most from Necitumumab ( Portrazza ) added to Gemcitabine and Cisplatin chemother ...


The aim of a study was to explore the efficacy and safety of Crizotinib ( Xalkori ) versus Platinum-based double agent chemotherapy as the first-line treatment in patients with advanced anaplastic lym ...


A study sought to test the hypothesis that in persons with episodic migraine, asthma is a risk factor for the onset of chronic migraine. Migraine and asthma are comorbid chronic disorders with epis ...


Studies have suggested a procoagulant state may be involved in promoting fibrosis via cell-surface receptor–mediated pathways providing biological plausibility for a mechanistic link between thrombosi ...


Idiopathic pulmonary fibrosis ( IPF ) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause occurring in adults. Radiologic and/or histopathologic patterns are ...


In a subset of patients with asthma, standard-of-care treatment does not achieve disease control, highlighting the need for novel therapeutic approaches. Lebrikizumab is a humanised, monoclonal anti ...


Eradication and suppression of Pseudomonas aeruginosa ( P. aeruginosa ) is a key priority in national guidelines for bronchiectasis, and is a major focus of drug development and clinical trials. An ac ...


Chronic obstructive pulmonary disease ( COPD ) is characterized by neutrophil-dominated airway mucosal inflammation and elevated neutrophil counts in sputum and lung tissue. CXC chemokine receptor 2 ( ...


No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa ( P. aeruginosa ) colonisation in bronchiectasis not due to cystic fibrosis. Researchers have evaluated the e ...


Idiopathic pulmonary fibrosis ( IPF ) is a progressive diffuse lung disease associated with an increased risk of lung cancer. Patients with idiopathic pulmonary fibrosis sometimes develop a life-threa ...


A study has examined the correlation between pre-operative coronary artery disease ( CAD ) and post-operative cardiovascular events in lung transplant recipients. Consecutive isolated lung transpla ...


This randomised double-blind placebo-controlled parallel-group multicentre phase IIa study evaluated the effect of the CXCR2 antagonist AZD5069 on sputum neutrophil counts in adults with bronchiectasi ...


Several cases of Burkholderia pseudomallei ( B. pseudomallei ) infection in cystic fibrosis have been previously reported. The aim of a study was to identify all cases globally, risk factors for acqui ...


Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postope ...